Ciafrè Silvia Anna

Subject: Biology and genetics

email: ciafre@uniroma2.it

office: 0672596059

Silvia Anna Ciafrè 

born in Pesaro, Italy, 28/01/1966

E-mail ciafre@uniroma2.it

 

Education and training

1989    University of Rome “La Sapienza”, Rome, Italy: PhD equivalent in Molecular Biology

 

Positions and Employment

1991-2000             University of Rome “Tor Vergata”, Rome, Italy: Research Assistant

2000-2005             University of Rome “Tor Vergata”, Rome, Italy: Researcher

2005- to present  University of Rome “Tor Vergata”, Rome, Italy: Associate Professor of Applied Biology

 

Other Professional Experience and Memberships

2000 Prof. M Izquierdo’s lab, Universidad Autonoma de Madrid, Madrid, Spain: Invited Scientist

2004 Prof. CM Croce’s lab, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA: Invited Scientist

2010 Dr. Jean Bénard’s lab, Département de Biologie et de Pathologie médicales, Service de Pathologie Moléculaire, Institut Gustave Roussy, 94800 – Villejuif, France: Invited Scientist

 

Member of the Società Italiana di Biofisica e Biologia Molecolare/Federazione Italiana Scienze della Vita (SIBBM/FISV).

Member of the Associazione Italiana Biologia e Genetica Generale e Molecolare (AIBG).

Member of the European Association for Cancer Research” (EACR).

  • Honors, Fellowships and Grants
  • 1990: Consiglio Nazionale delle Ricerche (National Research Council) (CNR), fellowship.
  • 1990: Società Italiana Biofisica e Biologia Molecolare (Italian Society for Biophysics and Molecular Biology) (SIBBM), thesis award.
  • 1998: Consiglio Nazionale delle Ricerche (National Research Council) (CNR) grant for a project entitled “Inibizione dell’angiogenesi e interferenza con la crescita tumorale: modelli in vitro e in vivo e analisi dei meccanismi molecolari” (Angiogenesis inhibition and impairment of tumor growth: in vitro and in vivo models and study of the molecular mechanisms). Role: Principal Investigator.
  • 2000: University of Rome Tor Vergata grants for young researchers for a project entitled “Uso di ribozimi contro il VEGF per inibire il potenziale neoangiogenico di linee cellulari di tumori cerebrali e ridurre la crescita tumorale in vivo” (Use of anti-VEGF ribozymes to inhibit the neoangiogenic potential of brain cancer cell lines and to reduce the in vivo tumor growth). Role: Principal Investigator.
  • 2000: Consiglio Nazionale delle Ricerche (National Research Council) (CNR) Agenzia 2000 grant for a project entitled “Uso di ribozimi contro il VEGF per inibire il potenziale neoangiogenico e ridurre la crescita di tumori cerebrali in modelli animali” (Use of anti-VEGF ribozymes to inhibit the neoangiogenic potential and reduce glioblastoma growth in animal models). Role: Principal Investigator.
  • 2002: FIRB-MIUR grant for a project entitled “Reelin: meccanismo di azione e funzione nella plasticità sinaptica” (Reelin: working mechanism and functions in synaptic plasticity). Role: Associated Investigator.
  • 2006 – 2007: Italian Ministry of University and Scientific Research (MIUR) grant. Project entitled “Effetti dell’espressione di reelina sulle proprietà di cellule staminali neurali murine” (Effects of Reelin expression on the properties of murine neural stem cells). Role: Principal investigator.
  • 2006 – 2008 : Italian Ministry of Health (Ministero della Salute) # 527B/2B/1.2 grant. Project entitled “Caratterizzazione dell’espressione di microRNA in sottopopolazioni cellulari di glioblastoma multiforme” (Characterization of microRNA expression in specific cell types in glioblastoma multiforme). Role: Co-investigator.
  • 2008 – 2011: PRIN # 20077YZTL8_002 Italian Ministry of University and Scientific Research (MIUR) grant for a project entitled “Ruolo dei microRNA nel differenziamento neuronale e nello sviluppo dei glioblastomi” (Role of microRNAs in neuronal differentiation and in glioblastoma development). Role: Co-investigator.
  • 2008 – 2011: Italian Ministry of University and  Scientific Research (MIUR) grant for a project entitled “Studio sul ruolo di miR-128 nel neuroblastoma” (Study about the role of miR-128 in neuroblastoma). Role: Principal investigator
  • 2012 – 2013: Fondazione Umberto Veronesi grant for a project entitled “CLIC1 (Chloride intracellular channel 1) as a possible prognostic indicator and therapeutic target in glioblastoma”. Role: Associated investigator.

 Scientific Interests By Keywords:

Glioblastoma

Cancer stem cells

RNA binding proteins

LncRNAs

Tumor Microenvironment

MicroRNAs

Tumor angiogenesis Neural stem cells

Prostate carcinoma Neuroblastoma

 

  • Ciafrè coordinates a group of researchers with background in biochemistry and in molecular and cell biology that has acquired extended expertise and international qualification on the study of different aspects of glioblastoma In 2004, S.A Ciafrè started to study microRNA expression in glioblastoma, thanks to a collaboration with Prof. Carlo Croce, at the Jefferson University of Philadelphia, USA. The data obtained by S.A. Ciafrè in Prof. Croce’s lab, confirmed and extended in Rome at the University of Tor Vergata, were published as the first example of an extensive study of microRNA differential expression in glioblastoma patients’ samples and cell lines. A further collaboration, with Dr. R. Agami, in Amsterdam, The Netherlands, has produced new data about the involvement of miR-221/222 in glioblastoma multiforme. At the same time, the role of miR-221/222 in cellular models of prostate carcinoma has been elucidated in SA Ciafrè’s lab by the discovery of p27 as a direct target of these two microRNAs, strongly affecting the proliferation of PCa cells. Furthermore, S.A Ciafrè’s group demonstrated the feasibility of the in vivo inhibition of miR-221 and miR-222 via antagomir transduction in PCa xenografts. S.A. Ciafrè took also part in a project of microRNA characterization of a large cohort of neuroblastoma samples resulting in the definition of specific microRNAs as novel prognostic markers. More recently, S.A. Ciafrè’s group published a work about a deep characterization of glioblastoma samples RNA expression, paving the way to novel studies on the different cell components of this heterogeneous and deadly tumor.

 

Publications

 

  1. Lucioli, A., Presutti, C., Ciafrè, S., Caffarelli, E., Fragapane, P. and Bozzoni, I.. “Gene dosage alteration of L2 ribosomal protein genes in S. cerevisiae: effects on ribosome synthesis”. Mol. Cell. Biol., 8: 4792-4798, 1988.    (i.f. 9,666)

 

  1. Della Seta, F., Ciafrè, S.-A., Marck, C., Santoro, B., Presutti, C., Sentenac, A. and Bozzoni, I.. “The ABF1 factor is the transcriptional activator of the L2 ribosomal protein genes in S. cerevisiae”. Mol. Cell. Biol., 10: 2437-2441, 1990.  (i.f. 9,666)

 

  1. Presutti, C., Ciafrè, S.-A. and Bozzoni, I.. “The ribosomal protein L2 in S. cerevisiae controls the level of accumulation of its own mRNA”. EMBO J., 10: 2215-2221, 1991.  (i.f. 13,999)

 

  1. Liguori A, Napoli C, Ciafrè SA, D’Armiento FP, Di Gregorio F, Bruzzese G, Di Ieso N, Di Benedetto A, Colasanti P, Ferrara A, et al. “Role of arterial hypertension in plasma secretion of prostacyclin during renal failure in man”. Riv Eur Sci Med Farmacol.  14 (5):305-8, 1992.

 

  1. D’Armiento FP, Di Gregorio F, Ciafrè SA, Posca T, Liguori A, Napoli C, Colasanti P, Cali A, Vecchione R. “Histological findings and evidence of lipid conjugated dienes and malonyldialdehyde in human fetal aortas”. Acta Paediatr. 82 (10):823-8, 1993.   (i.f. 1,315)

 

  1. Fazio, V.M., Barrera, G., Muraca, R., Rinaldi, M., Ciafrè, S., Lazzari, M., Dianzani M., and Farace, M.G. “Differentiating agents and cancer therapy. Role of lipid peroxidation and its product 4-hydroxynonenal in the control of cell proliferation and differentiation”. “Combination Therapies, 2”, Goldstein A.L. and  Garaci E,  ed. s, New York: Plenum Press, pp. 105-114, 1993.

 

  1. Fazio, V.M., Rinaldi, M., Ciafrè, S., Barrera, G., Farace, M.G.  “Control of neoplastic cell proliferation and differentiation by restoration of 4-hydroxynonenal physiological concentration”. Molec. Aspects Med. 14: 217-228, 1993.    (i.f. 1,3)

 

  1. Fazio, V.M., Fazio, S., Rinaldi, M., Catani, M.V., Zotti, S., Ciafrè, S., Seripa, D., Ricci, G., and Farace, M.G. “Accumulation of human apolipoprotein-E in rat plasma after in vivo intramuscular injection of naked DNA”.  Biochem. Biophys. Res. Comm., 200: 298-305, 1994. (i.f. 3,055)               

 

  1. Ciafrè, S.A., Rinaldi, M., Gasparini, P., Seripa, D., Bisceglia, L., Zelante, L., Farace, M.G. and Fazio, V.M. “Stability and functional effectiveness of phosphorothioate modified duplex DNA and synthetic “mini genes””. Nucl. Acids Res., 23: 4134-4142, 1995. (i.f. 5,396)

 

  1. Napoli C, Liguori A, Sorice P, di Benedetto A, Ciafrè S, Posca T, di Ieso N, D’Armiento FP. “Relations between vasoactive hormones and diastolic function in hypertensive uraemic patients”.  J Intern Med., 240 (6):389-94, 1996. (i.f. 2,273)

 

  1. Rinaldi, M., Ciafrè, S.A., Parrella, P., Farace, M.G., Fazio, V.M.. “Naked-gene transfer technology and somatic gene therapy approaches in adult and in utero.” Minerva Biotecnologica, vol 9, n.4, p. 254-265, 1997.  (i.f. 0,233)

 

  1. Napoli C, Di Gregorio F, Sorice P, Di Benedetto A, Ciafrè S, Posca T, Ferrara A, Di Paolo E, Bruzzese G, D’Armiento FP,  Mansi L, Liguori A. “High prevalence of myocardial ischemia and vasoconstrictive hormonal release in hypertension during chronic renal failure”. Nephron, 76 (4): 434-44, 1997.  (i.f. 1,818)

 

  1. Rinaldi, M., Ciafrè, S.A., Parrella, P., Signori, E., Farace, M.G., Saglio, G. and Fazio, V.M.. “Strategies to elicit anti-idiotypic immune response in B-lymphoma patients: peptide and genetic immunization.”Adv. Exp. Med. Biol, 451: 323 – 330, 1998. (i.f. 0,513)

 

  1. Ciafrè, S.A., Rinaldi, M., Vespignani, I., Parrella, P., Seripa, D., Signori, E., Ria, F., Farace, M.G., Fazio, V.M.. “A plasmid family containing two different expression cassettes suitable for immunomodulation and genetic immunization.” Plasmid, 40 (1): 84-89, 1998.  (i.f. 1,302)

 

  1. de Nigris F, Youssef T, Ciafrè S, Franconi F, Anania V, Condorelli G, Palinski W, Napoli C. “Evidence for oxidative activation of c-Myc-dependent nuclear signaling in human coronary smooth muscle cells and in early lesions of Watanabe heritable hyperlipidemic rabbits: protective effects of vitamin E”. Circulation, 102 (17):2111-7, 2000.   (i.f. 10,893)

 

  1. Rinaldi M., Catapano A.L., Parrella P., Ciafrè S.A., Signori E., Seripa D., Uboldi P., Antonini R., Ricci G., Farace M.G. and Fazio V.M. ” Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by intramuscular injection of plasmid DNA” Gene Therapy, 7: 1795 – 1801,  2000.  (i.f. 5,964)

 

  1. Rinaldi M., Ria F., Parrella P., Signori E., Serra A., Ciafrè S.A., Vespignani I., Lazzari, M.,  Farace M.G., Saglio G., and Fazio V.M. “Antibodies elicited by naked DNA vaccination against hypervariable VH-CDR3 idiotypic determinants of B-lymphoproliferative disorders specifically react with patients’s tumor cells.” Cancer Res., 61: 1555-1562, 2001.  (i.f. 8,460)

 

  1. Rinaldi M, Barrera G, Spinsanti P, Pizzimenti S, Ciafrè SA, Parrella P, Farace MG, Signori E, Dianzani MU, Fazio VM. “Growth inhibition and differentiation induction in murine erythroleukemia cells by 4-hydroxynonenal.” Free Radic Res., Jun; 34 (6): 629-37, 2001. (i.f. 2,493)

 

  1. Quattrocchi, C.C., Wannenes, F., Persico, A.M., Ciafrè, S.A., D’Arcangelo G., Farace, M.G., Keller, F. “Reelin is a serine protease of the extracellular matrix” Journal of Biological Chemistry,  277 (1): 303-309, 2002. (i.f. 7,368)

 

  1. Ciafrè S.A., Barillari G., Bongiorno Borbone L., Wannenes F., Izquierdo M. and Farace M.G. ” A tricistronic retroviral vector expressing natural antiangiogenic factors inhibits angiogenesis in vitro but is not able to block tumor progression in vivo“. Gene Ther., Feb.; 9 (4): 297 – 302, 2002.  (i.f. 5,964)

 

  1. Caporossi D, Ciafrè SA, Pittaluga M, Savini I, Farace MG. “Cellular responses to H2O2
    and bleomycin-induced oxidative stress in L6C5 rat myoblasts”, Free Rad. Biol. Med.,
    35 (11): 1355-1364, 2003. (i.f. 5,082)

 

  1. Ciafrè SA, Niola F, Wannenes F, and Farace MG. “An anti-VEGF ribozyme embedded within the adenoviral VA I sequence inhibits glioblastoma cells angiogenic potential in vitro”, J. Vasc. Res., Apr 7; 41(3): 220 – 228, 2004.  (i.f. 2,458)

 

  1. Wannenes F*, Ciafrè SA.*, Niola F, Frajese G and Farace MG. ”Vector-based RNA interference against Vascular Endothelial Growth Factor-A significantly limits vascularization and growth of prostate cancer in vivo”, Cancer Gene Ther., 12(12):926-934, 2005. (i.f. 3,653) *co-authors

 

  1. Ciafrè SA*, Galardi S*, Mangiola A, Ferracin M, Liu C-G, Sabatino G, Negrini M, Maira G, Croce CM, Farace MG. “Extensive modulation of a set of microRNAs in primary glioblastoma”, Biochem. Biophys. Res. Comm., 334(4):1351-8, 2005. (i.f. 2,904) *co-authors

 

  1. Rinaldi M., Signori E., Rosati P., Cannelli G., Parrella P., Iannace E., Monego G., Ciafrè SA., Farace MG., Iurescia S., Fioretti D., Rasi G., and Fazio VM. “Feasibility of in utero DNA vaccination following naked gene transfer into pig fetal muscle: transgene expression, immunity and safety”, Vaccine, 24(21):4586-91, 2006  (i.f. 2,824)

 

  1. Niola F., Evangelisti E., Campagnolo L., Massalini S., Buè MC., Mangiola A., Masotti A.,  Maira G., Farace MG., Ciafrè SA. “A plasmid-encoded VEGF siRNA reduces glioblastoma angiogenesis and its combination with interleukin-4 blocks tumor growth in a xenograft mouse model”, Cancer Biology and Therapy, 5(2):174-179, 2006. (i.f. 3,279)

 

  1. Ciafrè SA, Niola F, Giorda E, Farace MG, Caporossi D.CoCl2-simulated hypoxia in skeletal muscle cell lines: role of free radicals in gene up-regulation and induction of apoptosis”, Free Radic Res, 41(4):391-401, 2007. (i.f. 2,925)

 

  1. Galardi S., Mercatelli N., Giorda E., Massalini S., Frajese GV, Ciafrè SA, Farace MG. “MiR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1”, Journal of Biological Chemistry, 282(32):23716-24, 2007. (i.f. 5,582)

 

  1. le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, Mangiola A, Anile C, Maira G, Mercatelli N, Ciafrè SA, Farace MG, Agami R. “Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation”, EMBO J.,  26(15):3699-3708, 2007. (i.f. 8,662)

 

  1. Mannino S, Molinari A, Sabatino G, Ciafrè SA, Colone M, Maira G, Anile C, Arancia G, Mangiola A. “Intratumoral vs systemic administration of meta-tetrahydroxyphenylchlorin for photodynamic therapy of malignant gliomas: assessment of uptake and spatial distribution in C6 rat glioma model.”, Int J Immunopathol Pharmacol., 21(1):227-31, 2008. (i.f. 3,213)

 

  1. Mercatelli N, Coppola V, Bonci D, Miele F, Costantini A, Guadagnoli M, Bonanno E, Muto G, Frajese GV, De Maria R, Spagnoli LG, Farace MG, Ciafrè SA. “The inhibition of  the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice”, PLoS ONE, 3(12):e4029, 2008. (i.f. 4,351)

 

  1. Evangelisti C, Florian MC, Massimi I, Dominici C, Giannini G, Galardi S, Buè MC, Massalini S, McDowell HP, Messi E, Gulino A, Farace MG, Ciafrè SA. “MiR-128 upregulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness”, The FASEB J., 23(12):4276-87, 2009. (i.f. 7,049)
  2. Massalini S, Pellegatta S, Pisati F, Finocchiaro G, Farace MG, Ciafrè SA. “Reelin affects chain-migration and differentiation of neural precursor cells”, Mol. Cell. Neurosci., 42: 341-349, 2009. (i.f. 3,934)

 

  1. Mercatelli N, Dimauro I, Ciafrè SA, Farace MG, Caporossi D. “alphaB-crystallin is involved in oxidative stress-protection determined by VEGF in skeletal myoblasts”, Free Radic Biol Med. 49: 374-382, 2010. (i.f. 5,707)

 

  1. Galardi S., Mercatelli N., Farace MG., Ciafrè SA. “NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells”, Nucl. Acids Res., 39(9):3892-902, 2011 (i.f. 7,836)

 

  1. Doria M, Tomaselli S, Neri F, Ciafrè SA, Farace MG, Michienzi A, Gallo A. “ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor.J Gen Virol. 2011 May;92(Pt 5):1228-32. (i.f. 3,568)

 

  1. C-H Gattolliat, L Thomas, SA Ciafrè, G Meurice, G Le Teuff, B Job, C Richon, V Combaret, P Dessen, D Valteau-Couanet, E May, P Busson, S Douc-Rasy, and J Bénard. “Expression of miR 487b and miR-410 encoded by 14q32.31 locus is a prognostic marker in neuroblastoma”, Br. J. Cancer, Oct 25;105(9):1352-61. 2011 (i.f. 4,831)

 

  1. S. Galardi and S.A. Ciafrè. “microRNAs and RNA-binding proteins: a complex network of interactions and reciprocal regulations in cancer”, RNA Biol. 10(6): 935-42, 2013 (i.f. 4,933)

 

  1. Orecchini E, Doria M, Michienzi A, Giuliani E, Vassena L, Ciafrè SA, Farace MG, Galardi S.  “The HIV-1 Tat protein modulates CD4 expression in human T cells through the induction of miR-222”, RNA Biol. 2014 Mar 6;11(4). (i.f. 4,933)

 

  1. Fazi B, Sicari D, Galardi D, Farace MG, Maira G, De Bonis P, Anile C,  Mangiola A,  Ciafrè SA. “An integrated view of the transcriptome and miRNome of glioblastoma and peritumor tissues”, ANTICANCER RESEARCH  34(10): 5865,  OCT 2014 (i.f. 1,8)

 

  1. Cicchini C, de Nonno V, Battistelli C, Cozzolino AM, De Santis Puzzonia M, Ciafrè SA, Brocker C, Gonzalez FJ, Amicone L, Tripodi M. “Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29”. Biochim Biophys Acta. 2015 Aug;1849(8):919-29. (i.f. 5,44)

 

  1. Fazi, B., Felsani, A., Grassi, L., Moles, A., D’Andrea, D., Toschi, N., Sicari, D., De Bonis, P., Anile, C., Giovanna Guerrisi, M., Luca, E., Farace, M.G., Maira, G., Ciafrè, S.A., & Mangiola, A. (2015). “The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors” Oncotarget. 2015 Sep 8;6(26):22526-52. (i.f. 6,63)

 

  1. Luchetti, A.; Ciafrè, S.A.; Murdocca, M.; Malgieri, A.; Masotti, A.; Sanchez, M.; Farace, M.G.; Novelli, G.; Sangiuolo, F. A Perturbed MicroRNA Expression Pattern Characterizes Embryonic Neural Stem Cells Derived from a Severe Mouse Model of Spinal Muscular Atrophy (SMA). Int. J. Mol. Sci. 201516, 18312-18327. (i.f. 2,862)

 

  1. Orecchini E, Federico M, Doria M, Arenaccio C, Giuliani E, Ciafrè SA, Michienzi A.  The ADAR1 editing enzyme is encapsidated into HIV-1 virions. Virology. 2015 Sep 9;485:475-480. doi: 10.1016/j.virol.2015.07.027. [Epub ahead of print] (i.f. 3,321)

 

  1. Galardi S, Petretich M, Pinna G, D’Amico S, Loreni F, Michienzi A, Groisman I, Ciafrè SA. CPEB1 restrains proliferation of Glioblastoma cells through the regulation of p27(Kip1) mRNA translation. Sci Rep. 2016 May 4;6:25219. doi: 10.1038/srep25219. (i.f. 5,57)

 

 

 

 

Abstracts

  1. Bozzoni, I., Caffarelli, E., Ciafrè, S., Fragapane, P., Lucioli, A. and Presutti, C.. (1988) “Regulation of expression of the X. laevis L1 r-protein gene and evolutionary analysis of its yeast counterpart”.  Ribosome synthesis CSH pag. 112.

 

  1. Presutti, C., Lucioli, A., Ciafrè, S. e Bozzoni, I.. (1988) “Alterazione del dosaggio dei geni per la proteina ribosomale L2 in S.cerevisiae e complementazione tra la proteina ribosomale L2 e la sua omologa L1 di X. laevis”.  Atti del Convegno SIBBM, pag. 84.

 

  1. Presutti, C., Ciafrè, S., Santoro, B. e Bozzoni, I.. (1989) “Regulation of expression of ribosomal protein genes in S. cerevisiae”.  Atti del XIX Convegno FEBS, sez.TU47.

 

  1. Ciafrè, S.-A., Santoro, B., Presutti, C. e Bozzoni, I.. (1989) “Il fattore generale di trascrizione ABF1 regola i geni per la proteina ribosomale L2 in S. cerevisiae” . Atti del Convegno congiunto SIBBM-AGI, pag. 71.

 

  1. Presutti, C., Ciafrè, S.-A., Santoro, B. and Bozzoni, I.. (1990) “The regulation of the expression of the genes (A and B) encoding for the r-protein L2, in the yeast S. cerevisiae, has been extensively studied both at the transcriptional  and post-transcriptional levels”. Yeast, 6: S335, June 1990.

 

  1. S. A. Ciafrè, C. Presutti, B. Santoro, I. Bozzoni. (1990) “Functional analysis of the genes coding for the ribosomal protein L2 in the yeast S. cerevisiae“. Atti del First international young scientist conference “Problems and methods in molecular and cell biotechnology”. Pag. 5, September 12-18, 1990.

 

  1. Bozzoni, I., Caffarelli, E., Fragapane, P., Ciafrè, S., Santoro, B., Presutti, C.. (1990) “Post-transcriptional regulation of ribosomal protein genes in Xenopus and yeast”. Cell biology international reports, 14, pag. 28, sez. S95, September 1990.

 

  1. Presutti, C., Ciafrè, S.-A. and Bozzoni, I.. (1990) “Regolazione dell’espressione dei geni per la proteina ribosomale L2 in S. cerevisiae”. Atti del Convegno SIBBM, pag. 86.

 

  1. Presutti C., Caffarelli E., Ciafrè S.-A., Fragapane P., Lener M., Prislei S., Santoro B., Sperandio S. and Bozzoni I.. (1990) “Evolutionary comparison of the regulation of the ribosomal protein genes”. Recombinant DNA technologies in industry and agriculture: state of the art in Italy. 5: 81-87.

 

  1. Fazio, V.M., Rinaldi, M., Ciafrè, S., Lispi, M., Ravagnan, G., Scaravelli, G., Pachì, A. and Farace, M.G. “Possibile ruolo degli spermatozoi nella trasmissione dell’HIV”. Convegno Nazionale di Rendiconto Scientifico, “V Progetto di Ricerche sull’AIDS (1992), pg.26 Addendum, Orbetello (GR), 13-17 giugno, 1992

 

  1. Fazio, V.M., Rinaldi, M., Ciafrè, S., Lispi, M., Ravagnan, G., Bergamini, A., Capozzi, M. and Farace, M.G “DNA HIV non-integrato, intracellulare ed intravirionico”. Convegno Nazionale di Rendiconto Scientifico, “V Progetto di Ricerche sull’AIDS (1992), pg.25 Addendum, Orbetello (GR), 13-17 giugno, 1992.

 

  1. Fazio, V.M., Rinaldi, M., Ciafrè, S., Spinsanti, P., Bergamini, A., Capozzi, M. and Farace, M.G.” Modulation of HIV-induced apoptosis in Molt-4 T-cell line”. Convegno Nazionale di Rendiconto Scientifico, “Sixth research project on AIDS (1993), Progress Report p. 175, Orbetello (GR), Italia, 19-23 giugno, 1993.

 

  1. Fazio, V.M., Rinaldi, M., Ciafrè, S., Barrera, G., Farace, M.G. “Control of neoplastic cell proliferation and differentiation by restoration of 4-hydroxynonenal physiological concentration”. Proceedings of the International Workshop on “Modulation of cell proliferation and differentiation by free radicals and antioxidants”, Rome-Italy, October 8th, 1993.

 

  1. Fazio, V.M., Fazio, S., Rinaldi, M., Ciafrè, S., Seripa, D., Farace, M.G.  “Blood accumulation of human apo-E by in vivo direct intramuscular injection of naked DNA”. First Meeting of the European Working Group on Human Gene Transfer and Therapy, Baveno-Stresa, Italy, November 19-22, 1993, pag. 66.

 

  1. Ciafrè, S.-A., Spinsanti, P., Rinaldi, M., Aquino, A., Barrera, G., Zappalà, A., Farace, M.G., and Fazio, V.M. “Concentrazioni fisiologiche di 4-idrossinonenale inducono re-differenziamento di cellule eritroleucemiche mediante la modulazione della protein chinasi-C”.  XII Congresso Nazionale SIP, Società Italiana di Patologia, Cagliari, Ottobre 4-7, 1994, pag. 78.

 

  1. Rinaldi, M., Ciafrè, S.-A., Spinsanti, P., Clementi, F., Farace, M.G., and Fazio, V.M. “Terapia genica somatica mediante iniezione diretta di DNA nudo ricombinante nel muscolo”. XII Congresso Nazionale SIP, Società Italiana di Patologia, Cagliari, Ottobre 4-7, 1994, pag. 138.

 

  1. Fazio, S.A. Ciafrè, M. Rinaldi, D. Seripa, L. Bisceglia, M.G. Farace and P. Gasparini. “Study on the feasibility of phosphorothioate modification for the construction and expression of nuclease-resistant genes”. Advances in Gene Technology: Molecular Biology of Human Genetic Disease. Gene Therapy. W.J. Whelan et al. ed.s, IRL press at Oxford University press, p. 61, 1994.

 

  1. Fazio, Rinaldi, M., Ciafrè, S.A., Seripa, D. , Fazio, S. and Farace M.G. “In vivo expression of recombinant proteins by direct intramuscular gene transfer”. Advances in Gene Technology:, p. Molecular Biology of Human Genetic Disease. Gene Therapy. W.J. Whelan et al. ed.s, IRL press at Oxford University press, p. 60, 1994.

 

  1. Rinaldi, M., Ciafrè, S.A., Seripa, D., Gasparini, P., Farace, M.G. and Fazio, V.M.  “Studies on the transcriptional effectiveness and nuclease resistance of phosphorothioate-modified genes”. Proceedings of the Second Meeting of the European Working Group on Human Gene Transfer and Therapy, London (UK), November 18-21, 1994. Gene Ther. 1 (suppl.2): S12, 1994.

 

  1. Rinaldi, M., Ciafrè, S.A., Signori, E., Seripa, D., Parrella, P., Vespignani, I., Farace, M.G., Fazio, V.M., Uboldi, P. and Catapano, A.L. “Functional chronic correction of dyslipidemia in Apo-E deficient mice by direct intramuscular injection of naked plasmid DNA”. XII International Symposium on Drugs affecting Lipid  Metabolism, Houston (Texas), November, 7-10, 1995, pag. 17.

 

  1. Rinaldi, M., Ciafrè, S.A., Seripa, D., Signori, E., Parrella, P., Uboldi, p., Catapano, A., Farace, M.G. and Fazio, V.M. “Gene therapy of dislipidemia in Apo-E deficient mice by direct intramuscular injection of naked plasmid DNA”. Proceedings of the Third Meeting of the European Working Group on Human Gene Transfer and Therapy, Barcelona (SP), November 17-20, 1995. Gene Ther. 2 (suppl.1): S36, 1995.

 

  1. V. M. Fazio, M. Rinaldi, S.A. Ciafrè, E. Signori, D. Seripa, P. Parrella, I. Vespignani, M.G. Farace, P. Uboldi and A. L. Catapano. “Functional chronic correction of dyslipidemia in Apo-E deficient mice by direct intramuscular injection of naked plasmid DNA”. 66th Congress of the European Atherosclerosis Society, Florence (Italy), July 13-17, 1996, pag. 28.

 

  1. Rinaldi, M., Ciafrè, S.-A., Seripa, D., Signori, E., Parrella, P., Uboldi, P., Catapano, A., Farace, M.G. and Fazio, V.M. “ Correzione funzionale di una forma di dislipidemia in topi difettivi per l’Apo-E mediante iniezione diretta di DNA “nudo” nel muscolo”. Atti del Convegno congiunto ABCD AGI SIBBM, Riccione (RN), 2-5 Ottobre 1996. 1B30 pag. 37.

 

  1. Fazio, V.M., Rinaldi, M., Ria, F., Vespignani, I., Cilli, V., Ciafrè, S.A., Parrella, P., Signori, E., Serra, A., Farace, M.G. and Saglio, G. “Intramuscular plasmid injection elicits immune response to idiotypic determinants of B-lymphoma patients’ cells”. IV Congress of the Italian Society of Experimental Hematology, Roma, November 6-8, 1996. Haematologica 81, suppl. 5: 115.

 

  1. Fazio, V.M., Rinaldi, M., Ria, F., Vespignani, I., Cilli, V., Ciafrè, S.A., Parrella, P., Signori, E.,  Farace, M.G. and Saglio, G. “Strategy to elicit immune response against idiotypic CDR3H of B-lymphoma patients by genetic immunization”. III European Conference on Gene Therapy of Cancer, Berlin, September 11-13, 1997. Pag.147.

 

  1. Tricarico M., S.A. Ciafrè, Spinsanti, P., Farace, M.G., Bonmassar E., Fazio, V.M. and Rinaldi, M.. ” Effect of 4-hydroxynonenal, a product of lipid peroxidation, on NK susceptibility of human K562 target cells”. IIAR Conference 1997 on New Anticancer Agents, Athens, Greece, 12-15 October 1997. Anticancer Research 17, 6A, 4099-4100.

 

  1. Rinaldi, M., Franco, E., Zaratti, M., Rosati, P., Cannelli, G., Parrella, P., Signori, E., Ria, F., Ciafrè, S.A., Farace, M.G. and Fazio, V.M.. “Perinatal anti-HBS induced immunogenicity by in utero genetic vaccination” V International Congress “The prevention of liver diseases on the threshold of the third millenium”. Capri, May 21-23, 1998, pag. 20.

 

  1. Rinaldi, M., Parrella, P., Ciafrè, S.A., Ria, F., Vespignani, I., Signori, E., Farace, M.G., Saglio, G. and Fazio, V.M.. “Vaccinazione genetica anti-idiotipica in disordini linfoproliferativi B non-Hodgkin” XVI Congresso Nazionale SIP, Società Italiana di Patologia, Siena, Giugno 24-27, 1998, pag. 258.

 

  1. Rinaldi, M., Rosati, P., Cannelli, G., Ria, F., Parrella, P., Vespignani, I., Signori, E., Ciafrè, S.A., Farace, M.G. and Fazio, V.M.. “Trasferimento genico in utero nel muscolo fetale suino ed induzione di risposta immune mediante vaccinazione genetica”. XVI Congresso Nazionale SIP, Società Italiana di Patologia, Siena, Giugno 24-27, 1998, pag. 256.

 

  1. Fazio, V.M., Rinaldi, M., Parrella, P. Ciafrè, S.A. Ria, F. Vespignani, I., Signori, E., Serra, A., Farace, M.G., Saglio, G.. “Intramuscular plasmid injection may elicit immune response to the hypervariable CDR3H idiotypic determinants of B-lymphomas”. V Congresso Nazionale della Società Italiana di Ematologia Sperimentale, Siena, 23-25 Settembre 1998, pag.146.

 

  1. Bongiorno Borbone, L., Ciafrè, S.A., Vagnozzi, R., Signoretti, S., Floris, R., Castriota-Scanderbeg, A., Izquierdo, M. and Farace, M.G.. “Antiangiogenic retroviral vectors for gene therapy of malignant brain tumors”. 1998 Annual Meeting of the Society for Neuroscience, Los Angeles, California, Nov. 7-12, 1998, pag. 2159.

 

  1. S.A. Ciafrè, L. Bongiorno Borbone, G. Barillari e M.G. Farace. ” Costruzione di vettori retrovirali esprimenti fattori antiangiogenesi per la terapia genica di tumori cerebrali”. 1° Convegno FISV, Federazione Italiana Scienze della Vita, Riva del Garda (TN), 2-6 Ottobre 1999, pag. 192.

 

  1. Ciafrè, S.A.,  Barillari, G., Wannenes, F., Bongiorno Borbone, L., and Farace, M.G. “Multicistronic antiangiogenic retroviral vectors for the gene therapy of malignant brain tumors” Cancer Gene Therapy, 7(10): 1395 – 1396, 2000.

 

  1. Wannenes, F., Ciafrè, S.A., Bongiorno Borbone, L., Barillari, G., Moretti, C. e Farace, M.G. “Costruzione di vettori retrovirali esprimenti fattori antiangiogenesi per la terapia genica di tumori solidi” 2° Convegno FISV, Federazione Italiana Scienze della Vita, Riva del Garda (TN), 30 Settembre- 4 Ottobre 2000, pag. 215.

 

  1. Ciafrè, S.A., Wannenes, F., e Farace, M.G. “Uso di ribozimi anti-VEGF per inibire il potenziale neoangiogenico di linee cellulari di tumori cerebrali” 3° Convegno FISV, Federazione Italiana Scienze della Vita, Riva del Garda (TN), 21 – 25 Settembre 2001, pag. 203.

 

  1. Ciafrè, S.A., Wannenes, F., e Farace, M.G. “Vettori esprimenti ribozimi anti-VEGF per la terapia genica antiangiogenica di tumori cerebrali” V Congresso A.I.B.G., Associazione Italiana di Biologia e Genetica Generale e Molecolare, Perugia, 1 – 4 ottobre 2001, pagg. 94-95.

 

  1. Ciafrè S.A., Wannenes F., and Farace M.G.. “New anti-VEGF ribozymes to inhibit neoangiogenic potential of glioblastoma cell lines”, Genome Medicine: Gene Therapy for the Millenium. Roma, 30 settembre – 3 ottobre 2001.

 

  1. Ciafrè S.A., Wannenes F., and Farace M.G.. “New ribozymes targeting VEGF production to inhibit neoangiogenic potential of brain tumor cell lines” New treatments for brain tumors: gene therapy and neural stem cells. An international symposium, Parma, 17 – 20 ottobre 2001, pag. 49.

 

  1. Caporossi D., Ciafrè S., Parisi P., Farace M.G.. “Exercise-induced cellular and molecular changes in muscle”, Sixth annual congress of the European College of Sport Science (ECSS), Colonia (Germania), 2001.

 

  1. Ciafrè S.A., Wannenes, F,  Farace, M.G.. “In vitro targeting of glioblastoma cells neoangiogenic potential through anti-VEGF ribozymes”, Bull. Cancer 2002; 89 (5), pag. 543.

 

  1. Ciafrè S., Niola F., Farace M.G. Caporossi D.. “Gene upregulation and cellular response of muscle cells exposed in vitro to CoCl2-induced hypoxia”, Seventh annual congress of the European College of Sport Science (ECSS), Atene (Grecia), 2002.

 

  1. Caporossi D., Ciafrè S.A., Catani M.V., Savini I., Avigliano L., Farace M.G., Pittaluga M., Sabatini S., Parisi P.. “Cellular signal transduction and physical activity: the role of free radicals”, Seventh annual congress of the European College of Sport Science (ECSS), Atene (Grecia), 2002.

 

  1. Ciafrè S.A., Niola F., Wannenes F., and Farace M.G.. “In vitro reduction of VEGF secretion from the human glioblastoma cell line U87MG through an anti-VEGF ribozyme. The inhibition of angiogenic potential as a gene therapy approach for brain tumors”, 10th Meeting of the European Society of Gene Therapy (ESGT), Antibes, France, October 12-16, 2002 pag. 44.

 

44.  Wannenes F, Ciafrè S.A., Moretti C., Frajese G.,  Farace M.G..“Strategies for new protocols of gene therapy in human prostate cancer cell lines using antiangiogenic factors”, XXIX  Simposio della Società Italiana di Cancerologia (SIC), Genova, 27 – 30 ottobre 2002.
 
  1. Ciafrè S.A., Niola F., Wannenes F., and Farace M.G.. “Anti-VEGF ribozymes reduce in vitro VEGF secretion from U87 human glioblastoma cells: new strategies for antiangiogenic gene therapy of brain tumors.”  XXIX Symposium of the Italian Cancer Society “From molecular oncology to molecular therapeutics”, Genova, Italy, October 27-30, 2002, pag. 87.

 

  1. Ciafrè, S.A., Niola, F., Wannenes, F., Farace, M.G.. “Un ribozima anti-VEGF riduce il potenziale angiogenico in vitro di cellule U87 di glioblastoma umano: l’inibizione dell’angiogenesi come approccio di terapia genica dei tumori cerebrali.” VI Congresso Associazione Italiana Biologia e Genetica Generale e Molecolare (A.I.B.G.), Giardini Naxos (ME), 1-5 ottobre 2003, pag. 35.

 

  1. Niola, F., Ciafrè, S.A., Wannenes, F. e Farace, M.G..  “Inibizione dell’espressione del fattore angiogenico VEGF in linee cellulari di glioblastoma: dal ribozima al siRNA. Approcci per la terapia genica dei tumori cerebrali.” 5° Convegno FISV, Federazione Italiana Scienze della Vita, Rimini, 10–13 ottobre 2003, pag. 259.

 

  1. Mercatelli, N., Niola, F., Ciafrè, S.A., Farace, M.G. e Caporossi, D.. “Risposta cellulare di mioblasti C2C12 a trattamenti in vitro con VEGF esogeno.” 5° Convegno FISV, Federazione Italiana Scienze della Vita, Rimini, 10–13 ottobre 2003, pag. 274.

 

  1. Wannenes, F., Quattrocchi, C., Ciafrè, S.A., Marino, R., Hochleitner, E., Lottspeich, F., Keller, F. e Farace, M.G.. “Identificazione del dominio serin-proteasico di reelin mediante mutagenesi sito-diretta.” 5° Convegno FISV, Federazione Italiana Scienze della Vita, Rimini, 10–13 ottobre 2003, pag. 302.

 

  1. Dimauro, I, Niola, F., Ciafrè, S.A., Parisi, P., Farace, M.G. e Caporossi, D.. “I radicali liberi come mediatori della risposta cellulare e molecolare indotta in vitro dal CoCl2 nelle cellule muscolari.” 5° Convegno FISV, Federazione Italiana Scienze della Vita, Rimini, 10–13 ottobre 2003, pag. 331.

 

  1. V M Fazio, E Signori, F Ria, E Franco, P Rosati, G Cannelli, L Zaratti, E Iannace, G Monego, S Blogna, M G Farace, S A Ciafrè, R Filippetti, M Rinaldi. “Prospects of in utero gene therapy following naked plasmid injection into pig fetal muscle: transgenes expression, immunity and long-term safety.” 11th Meeting of the European Society of Gene Therapy (ESGT), Edinburgh, UK, November 14 – 17, 2003.

 

  1. Wannenes F., Ciafrè S.A., Farace M.G.,  Frajese G. and  Moretti C. “Anti-VEGF ribozymes inhibit neoangiogenic potential of  prostate cancer cell lines”. 85th Annual Meeting of the Endocrine Society, Philadelphia, PA, 2003.

 

  1.  S. Galardi, S.A. Ciafrè, A. Mangiola, C.M. Croce e M.G. Farace. “Studio dell’espressione dei microRNA nel glioblastoma de novo” VII Congresso Associazione Italiana Biologia e Genetica Generale e Molecolare (A.I.B.G.), Grado (GO) 23 – 26 settembre 2004, P17.

 

  1. C. Evangelisti, S. Massalini, F. Wannenes, S.A. Ciafrè, R. Panteri, F. Keller and M.G. Farace. “The subrepeat 2A-3B of the modular protein Reelin: cloning and characterization of its hypotetic catalytic role as a serine protease” 6° Convegno FISV, Federazione Italiana Scienze della Vita, Riva del Garda (TN), 30 settembre – 3 ottobre 2004, pag. 346.

 

  1. S. A. Ciafrè, S. Galardi, A.Mangiola, G. Maira, C.-G. Liu,  M. Ferracin, C.M. Croce and M.G. Farace. “Altered accumulation of specific microRNAs in glioblastoma de novo” 12th Meeting of the European Society of Gene Therapy (ESGT), Tampere, Finland, November 4 – 7, 2004, pag. 37.

 

  1. S.A. Ciafrè, S. Galardi, A. Mangiola, Maira, C., C.-G. Liu, G., M. Ferracin, Croce, M.G. Farace. “Altered accumulation of specific microRNAs in glioblastoma de novo”. Keystone symposia “Diverse roles of RNA in gene regulation”. Breckenridge, Colorado, USA, January 8-14, 2005. #117 page 42.

 

  1. S.A. Ciafrè, S. Galardi, A. Mangiola, C.-G. Liu, G., Sabatino,  M., M. Ferracin, Maira, C., Negrini, G. Croce, M.G. Farace. “MicroRNAs as regulators of gene expression in tumorigenesis and differentiation: the example of glioblastoma”. Advances in biology and treatment of malignant brain gliomas. Stem cells and neurosciences. Rome, September 23-24, 2005. Book of abstracts, pages 14-15.

 

  1. S. Galardi, S.A. Ciafrè, A. Mangiola, M. Ferracin, C.-G. Liu, G. Sabatino,  M. Negrini, G. Maira, C. Croce, M.G. Farace. “Studio dell’espressione dei microRNA nel glioblastoma multiforme e identificazione dei loro bersagli molecolari” VIII Congresso Associazione Italiana Biologia e Genetica Generale e Molecolare (A.I.B.G.), Sirolo (AN), 15-17 settembre 2005, pag. 13.

 

  1. N. Mercatelli, S. Galardi, S.A. Ciafrè, G. Frajese, M.G. Farace. “The differential expression of a cluster of  microRNAs correlates with p27 state in prostate carcinoma cell lines” 7° Convegno FISV, Federazione Italiana Scienze della Vita, Riva del Garda (TN), 22-25 settembre 2005, pag. D7.11.

 

  1. S. Massalini, M.C. Buè, P. Tunici, S.A. Ciafrè, G. Finocchiaro, M.G. Farace. “Reelin influences proliferation and migration of mouse adult neural stem cells” 7° Convegno FISV, Federazione Italiana Scienze della Vita, Riva del Garda (TN), 22-25 settembre 2005, pag. D4.10.

 

 

 

  1. Galardi S, Mercatelli N, Giorda E, Frajese G, Ciafrè SA, Farace MG. “La sovraespressione di miR-221 e miR-222 aumenta la proliferazione di linee cellulari di carcinoma della prostata e promuove, attraverso la regolazione post-trascrizionale di p27, il passaggio dalla fase G1 alla fase S del ciclo cellulare”, IX Congresso Associazione Italiana Biologia e Genetica Generale e Molecolare (A.I.B.G.), Massa Lubrense 11-14 settembre 2006, pag 43.

 

 

  1. Galardi S, Mercatelli N, Giorda E, Frajese G, Ciafrè SA, Farace MG. “MiR-221 and miR-222 expression affects the proliferation potential of prostate carcinoma cell lines by targeting p27”, VIII Convegno FISV, Federazione Italiana Scienze della Vita, Riva del Garda (TN), 28 settembre – 1 ottobre 2006, pag D01.13.

 

 

  1. Galardi S, Mercatelli N, Giorda E, Massalini S, Frajese G, Farace MG, Ciafrè SA. “The cell cycle inhibitor p27kip1 is a target of miR-221 and miR-222 in prostate carcinoma cell lines”, MiRNA symposium, RNAi Europe, Barcelona, Spain, 19-21 September 2007.

 

 

  1. C. Evangelisti, M.C. Florian, I. Massimi, C. Dominici, G. Giannini, S. Massalini, M.G. Farace, S.A. CiafrèMiR-128 reduces neuroblastoma cell motility and invasiveness by inhibiting Reelin and DCX expression”, X Convegno FISV, Federazione Italiana Scienze della Vita, Riva del Garda (TN), 24 – 27 settembre 2008, pag D01.02.

 

 

  1. Doria M., Gallo, A., Neri F., Tomaselli, S., Ciafrè, S.A., Farace, M.G., Michienzi, A. “The ADAR editing enzymes are novel HIV-1 proviral factors”, XII Congresso nazionale AIBG Associazione Italiana Biologia e Genetica Generale e Molecolare, 8-9 ottobre 2010, Trento, pag 63.

 

  1. Galardi, S., Ciafrè, S.A., Farace M.G. “Molecular dissection of the regulation of miR-21/222 in prostate carcinoma and glioblastoma”, XII Congresso nazionale AIBG Associazione Italiana Biologia e Genetica Generale e Molecolare, 8-9 ottobre 2010, Trento, pag 13.

 

  1. Doria M, Tomaselli S,  Neri F, Ciafre, SA, Farace MG, Gallo A, Michienzi A. “The ADAR editing enzymes are novel HIV-1 proviral factors”, INFECTION Vol.39 Pages: S13-S13 Supplement: 1 MAR 2011.

 

  1. S. Vincenti, A. Malgieri, A. Luchetti, M.C. Buè, F. Sangiuolo, M.G. Farace, S.A. Ciafrè “Characterization of brain and spinal cord neural stem cells (NSCs) derived from E13.5 SMAΔ7 mouse model”, SIBBM Seminar “Frontiers in Molecular Biology” Trieste, 26-28 May 2011, pag. 46.

 

  1. Galardi S, Orecchini E.,  Nasi S., Farace M.G., Ciafrè S.A. “Functional characterization of  Myc-modulated microRNAs in glioblastoma cancer stem cells” WORKSHOP “miRNAs and long ncRNAs in physiology and/or pathology” Santa Margherita Ligure, 02 Giugno 2012.

 

  1. Carla Cicchini, Valeria De Nonno, Silvia Anna Ciafrè, Laura Amicone and Marco Tripodi “Role of H19 non coding RNA in hepatocyte differentiation and epithelial identity” WORKSHOP “miRNAs and long ncRNAs in physiology and/or pathology” Santa Margherita Ligure, 02 Giugno 2012.

 

  1. C. Cicchini, V. De Nonno, S.A. Ciafrè, L. Amicone, M. Tripodi “The transcriptional factors SNAIL and HNF4α, respectively, EMT and MET master genes, oppositely regulate the antifibrogenic microRNA-29 family members”, XIV Congresso nazionale AIBG Associazione Italiana Biologia e Genetica Generale e Molecolare, Assisi-Perugia 28-29 settembre 2012.

 

  1. S.A. Ciafrè, B. Fazi, D. Sicari, S. Galardi, M. G. Farace, G. Maira, P. De Bonis, C. Anile,  A. Mangiola “An integrated analysis of transcriptome and miRNome of glioblastoma samples and peritumoral tissues provides a new insight into the molecular pathways perturbed in this tumor”, Advances in Biology and Treatment of Malignant Brain Gliomas International Congress – 2nd Edition Rome, June 12-13, 2014, pag.13-14.

 

  1. Silvia Galardi, Mauro Savino, Barbara Illi, Sara Beji, Serena Pellegatta, Federica Pisati, Giulio Pavesi, Maria Giulia Farace, Silvia Anna Ciafrè, Sergio Nasi. “Mechanism and therapeutic efficacy of Myc inhibition by Omomyc in glioblastoma”, Advances in Biology and Treatment of Malignant Brain Gliomas International Congress – 2nd Edition Rome, June 12-13, 2014, pag. 19.

 

  1. Fazi B, Sicari D, Galardi S, Farace MG, Maira G, De Bonis P, Anile C,  Mangiola A,  Ciafrè SA. “A molecular insight into glioblastoma samples and peritumor areas from short- and long-term survivors indicates pathways involved in tumor establishment and recurrence”, XVI Congresso Nazionale AIBG Napoli, 26-27 settembre 2014, pag 33.

 

  1. C. Cicchini, V. De Nonno, C. Battistelli, A.M. Cozzolino, S.A. Ciafrè, L. Amicone, M. Tripodi. “Epigenetic control of EMT/MET dynamics: HNF4 impacts DNMT3s through miRs-29”, XVI Congresso Nazionale AIBG Napoli, 26-27 settembre 2014, pag. 20

 

  1. Fazi B, Sicari D, Galardi D, Farace MG, Maira G, De Bonis P, Anile C,  Mangiola A,  Ciafrè SA. “An integrated view of the transcriptome and miRNome of glioblastoma and peritumor tissues”, 9th International Conference of Anticancer Research, 6-10 October 2014, Sithonia, Greece.

 

  1. Fazi B., Felsani A., Grassi L., Guffanti A., D’Andrea D., Toschi N., Sicari D., Farace M.G., Mangiola A., Ciafrè S.A. “Deep sequencing of glioblastoma tissues and peritumoral regions reveals mRNAs and microRNAs depicting molecular pathways shared by tumors and surrounding areas and highlights differences between short-term and long-term survivors”, EACR-AACR-SIC Special Conference 2015 -Anticancer Drug Action and Drug Resistance: from Cancer Biology to the Clinic, 20-23 June 2015, Florence, Italy.

 

 

 

 Book Chapters

“MiRNAs in glioblastoma”, chapter 16 (pages 348-360) of the book: “MicroRNAs from basic science to disease biology” edited by Krishnarao Appasani for Cambridge University press, Cambridge UK, 2008.

 

 

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