Sette Claudio

Subject: Human anatomy II and Clinical practice III

email: claudio.sette@uniroma2.it

office: 0672596260

 

Name: Claudio Sette

 

Education:

 

1985:   High School Degree, Instituto Liceo G. Piazzi Morlupo (Rome, Italy)

1992:   Doctor cum Laude in Biological Sciences, University of Rome La Sapienza (Rome, Italy)

1998:   PhD in Medical Embryology, University of Rome Tor Vergata, (Rome, Italy)

 

Current Position:                            

 

Associate Professor of Anatomy

Department of Biomedicine and Prevention,

School of Medicine

University of Rome Tor Vergata

Via Montpellier 1, 00133, Rome

Telefono 39672596260   FAX 39672596268

Email: claudio.sette@uniroma2.it

 

 

Professional Experience:

 

2012-to date   Associate Professor at the Department of Biomedicine and Prevention, University of Rome Tor Vergata, (Italy)

2010-to date   Associate Member of the European Alternative Splicing Network (EURASNET)

2006-to date   Joint appointment as Director of the Laboratory of Neuroembryology at the Fondazione Santa Lucia, Rome (Italy)

2008                Invited Scientist, Center for Reproductive Sciences, University of California at San Francisco, California U.S.A. (Host: Prof. Marco Conti)

2004                Invited Scientist, Department of Obstetrics and Gynecology, Stanford University, California U.S.A. (Host: Prof. Marco Conti)

2003                Invited Scientist, Department of Biological Sciences, Kobe University, Japan (Host: Prof. Yasuo Fukami)

2002-2012      Associate Professor at the Department of Public Health and Cell biology, University of Rome Tor Vergata, (Italy)

2001-2002      Assistant Professor at the Department of Public Health and Cell biology, University of Rome Tor Vergata, (Italy)

1998-2000      Postdoctoral Fellow at the Department of Molecular and Cell Biology, University of California at Berkeley (California, USA)

1995-1998      PhD student in Medical Embryology at the Department of Public Health and Cell biology, University of Rome Tor Vergata (Italy)

1995-1996      Invited Scientist at the  INSA,  School of Engeneering, Department of Biological Chemistry, INSERM Unit 352 , Lyon, (France). (December 1995- February 1996)

1993-1995      Research Fellow at the Department of Obstetrics and Gynecology, Stanford University, California U.S.A.

1990-1992      Undergraduate Internship at the Department of Biological Chemistry, University of Rome La Sapienza (Italy).

 

Awards:

 

1992                Research Fellowship by the Fondazione Cenci-Bolognetti, University of Rome La Sapienza.

1993-1995      Dean’s Fellowship by Stanford University (California, USA).

1998-2000      Postdoctoral Fellowship by the American-Italian Cancer Foundation.

 

Scientific Societies and Networks:

 

2010-to date   European Alternative Splicing Network of Excellence (EURASNET);

2010-to date   Società Italiana di Anatomia ed Istologia (SIAI);

2010-to date   Società Italiana di Biofisica e Biologia Molecolare (SIBBM);

2011-to date   Associazione di Biologia Cellulare e del Differenziamento (ABCD).

 

Bibliometrics:

 

H Index Web of Science (ISI): 35

H Index Scopus: 38

H Index Google Scholar: 43

 

Abilitazione ANVUR Professore I fascia:

 

05/H1 Anatomia Umana (2012)

05/H2 Istologia (2012)

05/F1 Biologia Applicata (2012)

 

Academic Teaching:

 

2013-to date   Professor of the Human Anatomy II course at the School of Medicine of the University of Rome Tor Vergata (English language).

2009-to date   Professor of the Human Anatomy II course at the School of Medicine of the University of Rome Tor Vergata (Italian language).

1999-to date   Professor of the Microscopic Anatomy course at the School of Medicine of the University of Rome Tor Vergata (Italian language).

2011-2013      Professor of the Human Anatomy course at the School of Dentistry of the University of Rome Tor Vergata.

2009-2012      Human Anatomy course at the School of Dentistry of the Università Nostra Signora del Buon consiglio, Tirana, Albania.

2005-2012      Human Anatomy I and Human Anatomy II courses at the School of Medicine of the Università Nostra Signora del Buon consiglio, Tirana, Albania.

1999-2013      Professor of the Human Anatomy course in the integrated course of Anatomy and Physiology for the school of Nursing Sciences at the School of Medicine of the University of Rome Tor Vergata.

1999-2013      Professor of the Human Anatomy course in the integrated course of Anatomy and Physiology for the school of Obstetrics at the School of Medicine of the University of Rome Tor Vergata.

1999-2002      Teaches the Optional Courses “La gonade maschile”, (3 seminars/year), and “Isolamento ed utilizzo delle cellule staminali (2 seminars/year) in the course of Human Anatomy at the School of Medicine of the University of Rome Tor Vergata.

1998-1999      Participates in educational activities at the Chari of Human Anatomy of the School of Medicine of the University of Rome Tor Vergata.

 

Research Teaching:

 

2012-to date   member of the Teaching Committee of the PfD Course in Biotecnologie Mediche e Medicina Traslazionale, Università di Roma Tor Vergata.

2002-2011      member of the Teaching Committee of the PhD Course in Scienze e Biotecnologie della Riproduzione e dello Sviluppo, Università di Roma Tor Vergata.

2007-2010      member of the Teaching Committee of the PhD Course in Scienze e Tecnologie Cellulari, Università di Roma La Sapienza.

 


Scientific Profile

 

Dr. Claudio Sette graduated in Biological Sciences in 1992 at the University of Rome La Sapienza, with a Thesis in Biochemistry, and took his PhD at the University of Rome Tor Vergata (1998), with a Thesis in Developmental Biology.

During his career, Dr. Sette spent two long-term stays abroad. First, we worked in the laboratory of Professor Marco Conti at the Stanford University, California, USA, where he studied signal transduction and cell proliferation in endocrine cells (1993-1995). His studies lead to the discovery of a negative feedback regulation in the cAMP signal transduction pathway, mediated by phosphorylation of the cAMP degrading enzyme phosphodiesterase. In 1998, Dr. Sette joined the laboratory of Professor Jeremy Thorner, in the Department of Molecular and Cell Biology at the University of California at Berkeley, USA (1998-2000), where he studied signal transduction and cell cycle control in yeast cells. Here, Dr. Sette also learned the basic knowledge of yeast genetics and how to apply these tools to questions in mammalian biology.

He returned to Italy in 2001, where he was appointed as Assistant Professor in Human Anatomy at the Department of Public Health and Cell Biology of the University of Rome Tor Vergata. In 2002, Dr. Sette was promoted to Associate Professor. He was Invited Scientist at the University of Kobe (2003), Japan, where he collaborated with Professor Yasuo Kukami, at the Stanford University (2004) and at the University of California at San Francisco (2008), where he collaborated with Professor Marco Conti. In 2006, Dr. Sette was enrolled as Director of the Laboratory of Neuroembryology at the Fondazione Santa Lucia in Rome. In 2010, Dr. Sette was elected Associate Member of the European Alternative Splicing Network of Excellence (EURASNET).

Dr. Sette has established his independent research group starting in January 2001. The focus of his research is on gene expression programs and the impact that signal transduction pathways exert on this regulation. Emphasis is given to the role splicing and mRNA translation in cell differentiation and its impact in various human diseases. In particular, the laboratory is interested in identifying splicing factors involved in germ cell and neuronal differentiation or contributing to human diseases. Current studies are focused on molecular processes involved in embryonic and adult neurogenesis under normal conditions or in neurodegenerative diseases. For instance, we have demonstrated the implication of the splicing factor SAM68 in the regulation of SMN2 splicing in Spinal Muscular Atrophy (SMA) patient’s cells and in a mouse model of the disease. In collaboration with physicians, we have performed studies to narrow down signalling pathways and splicing regulatory mechanisms that are aberrant in patients affected by various cancers, including glioblastoma, testicular, prostate and pancreatic carcinomas.

Our studies aim at translating new findings in basic biology into the development of biologic drugs to interfere with protein functions in pathological situations. We have developed tools to rescue the expression of the SMN protein, which is considered the therapeutic target of SMA (now covered by a Patent approved by the European Commission as a new potential therapeutic strategy for correction of the genetic defect in SMA patients). Moreover, in collaboration with a pharmaceutical company based in Rome (Sigma-tau) we developed small synthetic inhibitors that target specific proteins involved in inflammatory diseases (now commercialized by Imgenex, California, USA).

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